Journal de dermatologie et des maladies dermatologiques

Comparison Treatment of Vitiligo by Co-culture of Melanocytes Derived from Hair Follicle with Adipose-Derived Stem Cells with and without NB-UVB

Abstract

Ahmed A Saleh, Osama H Abdel-salam, Hala G Metwally, Hany A Abdelsalam, Ayman M Hassan and Walaa S Sosa

Objective: The aim of this work is to evaluate treatment of vitiligo by co-culture of melanocytes derived from hair follicle with adipose-derived stem cells with (NB-UVB) and without (NB-UVB). Patients and methods: In this study, we used co culture of adipose derived stem cell with melanocytes derived from hair follicle in treating different types of stable resistant vitiligo, by two methods transplantation: group (A) exposed to (NB-UVB), group (B) did not expose to (NB-UVB). They are followed up for 3 months. Results: At the end of the follow up period which was 3 months group (A) showed better pigmentary response than group (B) and it was highly statistically significant. Stability, size, site and onset of vitiligo appeared to be important factors affecting treatment results. Using (NB-UVB) also after injection of the treatment showed more improvement in the treatment results. Conclusion: Co-culture of adipose derived stem cell with melanocytes derived from hair follicle could be a safe and effective method of treatment for stable localized vitiligo in patients resistant to other methods of therapy.