Hépatologie et science pancréatique

The Interplay between Non-alcoholic Fatty Liver Disease and Cardiovascular Health: A Comprehensive Review

Abstract

Kiara Rosella*

Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as a global health concern, affecting approximately 25% of the world's population. Initially recognized as a hepatic manifestation of metabolic syndrome, NAFLD's implications extend far beyond the liver, significantly impacting cardiovascular health. This comprehensive review delves into the intricate relationship between NAFLD and Cardiovascular Disease (CVD), shedding light on their shared pathophysiological mechanisms, diagnostic challenges, and therapeutic implications. Public health initiatives aimed at promoting healthy lifestyle behaviours, including balanced nutrition, regular physical activity, and smoking cessation, are pivotal in reducing the prevalence and severity of both NAFLD and CVD. Community-based screening programs leveraging non-invasive diagnostic modalities hold promise in identifying high-risk individuals at an early stage, facilitating timely intervention and risk factor modification. Shared risk factors such as obesity, insulin resistance, dyslipidemic, and hypertension form the cornerstone of the NAFLD-CVD nexus.