Journal de néphrologie et thérapeutique

Phenyramidol Induced Acute Tubular Necrosis

Abstract

Omer Celal Elcioglu *,Abdullah Ozkok ,Ali Bakan ,Yasemin Ozluk ,Isin Kilicaslan ,Ali Riza Odabas

Phenyramidol is a moderately effective, non-narcotic analgesic and muscle relaxant. It acts by interneuronal block in the spinal cord and brain stem. The clearance of the drug becomes in the liver via glucuronidation. Conjugated form of the drug is excreted through the kidneys [1]. It is not available in the US or, with the exception of Turkey, in Europe. It is widely used for musculo-skeletal pain such as acute lumbago and chronic back pain in the Asia and Turkey, with or without NSAÃ?â??Ã?°Ds. It rarely causes gastrointestinal discomfort and there are some reported cases of hepatotoxicity [2]. To the best of our knowledge, nephrotoxicity has not been reported yet. Herein, we reported a case of Acute Tubular Necrosis (ATN) possibly due to the use of phenyramidol for backache.