Journal de Morphologie et d'Anatomie

A Comprehensive Analysis of How Chronological Age Affects Mesenchymal Stromal Cells' Ability to Chondrogenesis

Abstract

Tillerson Harkonen*

Mesenchymal Stromal Cells (MSCs) hold immense potential in regenerative medicine, particularly in cartilage repair and regeneration. However, the impact of chronological age on the chondrogenic capacity of MSCs remains a subject of intense investigation and debate. This article provides a comprehensive analysis of the relationship between chronological age and MSCs' ability to undergo chondrogenesis. Through an examination of relevant studies, key factors influencing age-related changes in MSCs, such as proliferation capacity, differentiation potential, gene expression profiles, and extracellular matrix composition, are discussed. Additionally, strategies to overcome age-related limitations and enhance chondrogenic potential are explored. Understanding the age-related dynamics of MSCs in chondrogenesis is crucial for optimizing regenerative therapies and addressing challenges associated with cartilage repair in aging populations.