Journal des complications et de la médecine du diabète

Wnt Ligand's Complicated Role in Type 2 Diabetes

Abstract

Ozlem Cakici

One of the major chronic diseases, type 2 diabetes mellitus (T2DM) can cause a variety of serious complications and is on the rise worldwide. Wnt ligands (Wnts) and the Wnt signaling pathways that activate Wnts are tightly regulated in a number of processes that are crucial to the onset and progression of T2DM and its complications. Due to the many Wnt family members and the conflicting effects of activating the canonical and/ or non-canonical Wnt signaling pathways, our understanding of their roles in these diseases is, however, very basic.