Journal de médecine du sport et d'études sur le dopage

The Immediate, Short-term and Long-term Impact of Endurance Exercise on Skeletal Muscle Transcriptome Profiles

Abstract

Fortiton Caroline*

This study investigates the dynamic impact of endurance exercise on skeletal muscle transcriptome profiles across immediate, short-term and long-term durations. Transcriptomic analysis reveals significant alterations in gene expression patterns associated with exercise-induced adaptations in skeletal muscle. Immediate responses are characterized by rapid changes in gene expression related to metabolic regulation and cellular stress response pathways. Short-term adaptations involve the modulation of gene networks governing muscle repair, angiogenesis and energy metabolism. Long-term effects are marked by sustained alterations in gene expression associated with enhanced muscle endurance, fiber remodeling and oxidative capacity. The comprehensive understanding of these transcriptomic changes provides insights into the molecular mechanisms underlying exercise-induced skeletal muscle adaptations, with implications for optimizing training strategies and developing targeted interventions for improving athletic performance and health outcomes.