Journal des complications et de la médecine du diabète

The Association of FokI Polymorphism with Vitamin D deficiency in Indian Diabetic Population

Abstract

Vinay Singh

Aim: To determine the association of vitamin D deficiency and the FokI polymorphism of the vitamin D receptor (VDR) gene in Indian diabetic population.

Methodology: The proposed study was conducted in the Department of Medicine and Department of Biochemistry, Maulana Azad Medical College, New Delhi, India and included 162 Type 2 Diabetes Mellitus (T2DM) patients of age 50 years and above who have a history of diabetes for more than five years. Patients who were already taking Vitamin D supplements were excluded from this study. SPSS software was used to analyze the data.

Results: It was found that Vitamin D deficiency (serum 25(OH)D < 20 ng/mL) was more prevalent in wild type (TT) genotype. The association of Vitamin D levels with the FokI polymorphism indicated that there was a progressive increased in Vitamin D levels associated with genotype i.e. patient with wild type (TT) genotype had the lowest level of Vitamin D followed by TC (heterozygous mutant) and CC (mutant). Thus the differential distribution of Vitamin D levels reached a good statistical significance (p=0.0001).

Conclusion: CC (mutant) genotype was found to be associated with maximum Vitamin D levels in Indian diabetic patients. Therefore, maintaining an optimal vitamin D level should be a high priority for diabetic patients in India