Journal des complications et de la médecine du diabète

Mitochondria-associated Membranes: Regulating Cellular Homeostasis and the Exercise-induced Mitochondrial Impact on Insulin Resistance

Abstract

Markus Pell

Mitochondria-Associated Membranes (MAMs) serve as critical interfaces between mitochondria and the Endoplasmic Reticulum (ER), orchestrating various cellular processes essential for maintaining homeostasis. Dysregulation of MAMs has been implicated in several pathological conditions, including insulin resistance. Exercise, a cornerstone of preventive medicine, exerts profound effects on mitochondrial function and insulin sensitivity. This article explores the intricate roles of MAMs in cellular homeostasis, the interplay between MAMs and insulin resistance and the potential therapeutic implications of exercise in mitigating insulin resistance through modulating MAMs.