Journal des complications et de la médecine du diabète

Efficacy of Herbal Remedies on Insulin Resistance and Oxidative Stress in Streptozotocin-Induced

Abstract

Khegay Hendy

Rats were used to study the antioxidant capacities of amla extracts and their impact on the oxidative stress in streptozotocin-induced diabetes. The streptozotocin-induced diabetic rats were given amla orally for 20 days in the form of either the commercial enzymatic extract Sun Amla or a polyphenol-rich fraction of ethyl acetate extract. Strong free radical scavenging action was demonstrated by amla extracts. Moreover, the formation of advanced glycosylated end products was significantly inhibited by amla. The oral administration of amla extracts to diabetic rats considerably reduced several oxidative stress markers in their serum while also somewhat improving body weight growth.