Journal des complications et de la médecine du diabète

Domperidone: Mechanism of Action and Clinical Uses

Abstract

Smith Kay*

Domperidone is a dopamine receptor antagonist that exerts its effects primarily in the gastrointestinal tract. It is widely used to manage gastrointestinal motility disorders such as gastroparesis and nausea associated with various conditions, including chemotherapy and Parkinson's disease. This comprehensive review explores the mechanism of action of domperidone, its pharmacokinetics, clinical uses across different patient populations, efficacy, safety profile, and current controversies surrounding its use.