Journal des complications et de la médecine du diabète

BPF Induces Hyperglycemia by Upregulating Oxidative Stress-Responsive Mir-200 Family, Targeting Mettl14 and Xiap in Insulin-Producing β Cells

Abstract

Jacopo Pascali

Bisphenol A (BPA) and its analogs are widely used chemicals in the manufacturing of various consumer products such as plastics, food packaging and thermal papers. However, recent studies have shown that exposure to these chemicals can disrupt glucose homeostasis in the body, leading to metabolic disorders such as diabetes and obesity. One such analog of BPA is Bisphenol F (BPF), which has been found to trigger hyperglycemia by acting on insulin-producing β cells in the pancreas. BPF exposure upregulates the expression of miR- 200 family in the pancreas which in turn targets two critical genes, Mettl14 and Xiap, leading to pancreatic apoptosis.