Journal des complications et de la médecine du diabète

A Hunt for Innovative Therapies to Treat Diabetic Neuropathy via Drug Repurposing

Abstract

Oliver Thomas

Chronic complications of diabetes mellitus include diabetic neuropathy. Diagnosis and treatment of diabetic neuropathy remain elusive due to concerns about the safety and efficacy of current treatments. Repurposing old drugs for new therapeutic approaches sounds promising, given the difficulties associated with discovering new drugs. This review focuses on the current pharmacological and non-pharmacological treatments for diabetic neuropathy as well as the molecular pathways involved in its progression. In addition, a holistic and mechanism-centric drug repurposing strategy is used to identify existing medications as potential new therapies for diabetic neuropathy. Additionally, the current state of diabetic neuropathy clinical research is brought to light. In conclusion, the barriers to drug repurposing are identified to pique the researchers' interest in overcoming them and rapidly bringing the drugs to diabetic neuropathy patients.