Journal de pharmacognosie et de produits naturels

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Background:Acute kidney injury is a serious medical condition that usually results in sudden loss of renal function and high mortality rate in the world. The efficacy and the mechanisms of ethanol leaf extract of Moringaoleifera in promoting recovery from glycerol induced acute kidney injury (AKI) in rats was investigated in this study. Methods: Thirty-five adult male Wistar rats were randomly sorted into five groups of seven animals each. Control received distilled water alone, Untreated group received single glycerol (4 ml/kg) intramuscularly, two groups were pretreated orally with 50 and 100 mg/kg of Moringaoleifera respectively for seven days and then injected with a single glycerol (4ml/kg) subcutaneously on day eight. Another group received oral administration of Moringaoleifera alone at 100 mg/kg for seven days. The animals were later sacrificed through cervical dislocation twenty-four hours after glycerol was administered. Results:Serum and renal homogenate analysis revealed that glycerol induced significant increases in creatinine kinase renal band, nitric oxide, malondialdehyde, protein carbonyl, myeloperoxidase, advanced oxidative protein products alongside a decrease in superoxide dismutase, reduced glutathione, glutathione peroxidase and an increase in the expression of Kidney Injury Molecule-1 (KIM-1) and Nuclear Factor Kappa Beta (NF-kB) using immunohistochemistry. Treatment with Moringaoleifera at both doses used brought on a reversal of these. Conclusion: These results support the hypothesis that oral administration of methanol stem extract of Moringaoleifera is effective in abrogating oxidative stress, attenuating inflammation, and enhancing nephrogenic repair after glycerol-induced AKI.

Drug Formulation Congress-2020 Conference Committee is glad to announce 36th International Conferences on “Pharmaceutical Formulation and Drug Delivery” during December 01-02, 2020 Kyoto, Japan. The Drug Formulation Congress-2020 theme has broad interests, many aspects and describes drug design is the approach of inventing revolutionary medicines. Drug design and Drug formulation defines the design of molecules that are corresponding in form and price to the bio molecular target with which they interact and consequently will bind to it.

Journal of Pharmacognosy and Natural Products is an open access journal which provides everyone with a forum to read articles without paying any charge. JPNP's main purpose is to provide current and latest medicinal plant growth. Herbal plants, chemical sweetener, lavender oil, natural food medicines, organic herbs, phototherapy, allergens, marine pharmacognosis, etc. are the main highlights of this journal.