Médecine moléculaire et génétique

Introduction: The aim of this article is to analyze the amount of pain during 4 days treatment with Chlorine dioxide in patients with oral inflammation (pericoronitis and acute necrotizing ulcerative gingivitis).

Methods: A visual analogue scale for pain (EVA scale) during a period of 4 days of treatment with Chlorine dioxide was given to patients. The scale used for this study measures from 0-10 the intensity of the pain with a series of "faces" that show the intensity in the pain experimentation.

Results and Discussion: A total of 172 patients were analyzed, 101 males and 71 females, aged between 14 and 28 years (mean 19 years). Patients were divided in 2 groups according to the pathology. The first group with 140 patients presented wisdom pericoronitis and were divided in 2 subgroups of 83 males and 57 females. The second group presented with ANUG with a total of 32 patients (18 males and 14 females). 83 males with pericoronitis had an average pain at the beginning of treatment of 9.7 (SD 0.5) and the 57 females 9.8 (SD 0.5). The 32 patients with ANUG (18 males and 14 females) had an average initial pain score of 10.0. By the end of the first day, pain had reduced in male patients with pericoronitis to 3.9 (SD 0.4) and in females to 4.0 (SD 0,4). On the second day it dropped to 2.9 (SD 0.4) and 3.0 (SD 0.4) respectively, on the third day to 1.0 (SD 0.3) and 1.1 (SD 0,3) in females, and on the last day 0.0 and 0.1.

Patients with ANUG had a higher pain score at baseline 10.0 for both men and women. At the end of the first day, the pain dropped to 4.7 (SD 0.9) in male and 4.9 (SD 0.9) in female. On the second day the pain dropped to 3.4 (SD 0.5) and 3.6 (SD 0.5) respectively. On the third day the pain was 2.3 (SD 0.5) and 1.3 (SD 0.5) respectively and on the last day 0.3 and 0.2.

No medications such as analgesics, anti-inflammatory or antibiotics drugs were prescribed during the follow-up period. The biggest change occurs on the first day with a very significant decrease in pain, going from worst to moderate.

Conclusion: This study demonstrates a high level of efficacy of Chlorine dioxide in the treatment of pericoronitis and ANUG where the pain was reduced from worst to mild in 2 days.