Journal de bio-ingénierie et des sciences biomédicales

Transport of Indomethacin from Kappa-Carrageenan based Nanogel

Abstract

Singh S, Thakur G and Avadhani KS

An effort has been made to prepare gel matrices using different concentrations of Carrageenan whose particle sizes could be exploited in the nanoscale. The Single emulsion technique has been employed for gel formulation. After formulation, gels were characterized for their particle size and zeta potential. Fourier Transform Infrared Spectroscopy (FTIR) was used in the analysis of nanogels, scanning electron microscopy (SEM) to envision the surface microstructures was also performed. It was found that average particle size was in the range of 2000- 4000 nm after drug entrapment and the particles were found to be spherical in shape. The entrapment efficiency of the model drug (Indomethacin) in gel matrix was found to be nearly 40%. Finally, the in vitro release profiles of indomethacin from the nanogel matrices were evaluated spectrophotometrically at 266 nm. Drug release from nanogel consisting of 4% carrageenan was found to be 68% for up to 24 h. Finally, the results have indicated that the Carrageenan nanogel carriers could be used for drug delivery applications.