Médecine moléculaire et génétique

The Use of Recombinant PrP in Research Concerning Transmissible Spongiform Encephalopathies

Abstract

Chloe Harrington

Transmissible Spongiform Encephalopathies (TSEs) are a group of fatal neurodegenerative diseases affecting both humans and animals. The underlying cause of these disorders involves the misfolding and aggregation of the Prion Protein (PrP). Investigating the mechanisms behind TSEs requires a deep understanding of PrP's structure and function. Recombinant PrP technology has emerged as a pivotal tool in TSE research, offering precise control and manipulation of PrP variants. This article delves into the significance and applications of recombinant PrP in unraveling the complexities of TSEs, highlighting its contributions in diagnostics, therapeutics, and the fundamental understanding of prion biology.