Développement et applications des biocéramiques

Synthesis of Sulfate-ion-substituted Hydroxyapatite from Amorphous Calcium Phosphate

Abstract

Takeshi Toyama, Shunichi Kameda and Nobuyuki Nishimiya

The composition of Hydroxyapatite (HAp) is expressed by the formula Ca₁₀(PO₄)₆(OH)₂. Many reports have been published on the synthesis of HAp in which Ca ions are substituted by various cations (e.g., Sr, Ba). On the other hand, studies on the synthesis of sulfate-ion-substituted hydroxyapatite (SAp) have rarely been conducted. The present study investigated the conditions for the synthesis of SAp from amorphous calcium phosphate (ACP, Ca₃(PO₄)^2- nH₂O) as the starting material, which can readily incorporate various ions into its structure. Sodium sulfate (Na₂SO₄) was added to ACP, and then, the mixture was hydrothermally processed at 220°C for 3 h. SAp obtained under these conditions had a Ca-deficient-type HAp structure. The SO₄/PO₄ molar ratio in SAp increased with increasing amounts of added Na2SO4, reaching a maximum value of 0.5, meaning that 1/3 of the PO₄^3- ions contained in HAp were substituted by SO₄^2- ions.