Revue des sciences chimiques

Synthesis of Some New Quinazoline Derivatives and Theoretical Studies of their Geometries

Abstract

R Kaur, M Bansal, B Kaur

Quinazoline and their fused-ring systems are well known for their potential biological activity. Inspired by this and in view of the usefulness of heterocyclic thiols as vulcanization accelerators, new derivatives viz. Quinazoline-2-thiols were prepared. These were synthesized by the condensation of 2-[isothiocyanato(substituted phenyl)methyl]-3,4-dihydronaphthalene-1(2H)-one with primary aromatic amines. All the prepared compounds have been characterized by elemental analysis, IR and mass spectroscopy