Revue des sciences chimiques

Synthesis and Pharmacological Evaluation of Some Pyrazoles, Thiazolopyrimidine, Triazolopyrimidine, Pyridone and 2-Iminochromene Containing Naproxenoyl Moiety as NSAIDs

Abstract

MA Salem, HKH Thabet, MH Helal, AS Abdelaal, YA Ammar

Some novel pyrazoles, thiazolopyrimidine, triazolopyrimidine derivatives containing naproxenoyl moiety were synthesized from the reaction of enaminone derivative 2 with some hydrazines and aminoheterocyclic compounds. Also, some thiazoles were obtained via condensation of acetyl derivative 1 with thiosemicarbazide followed by in situheterocyclization with α-halogenated reagents. Most of the target compounds were then evaluated for their animal toxicity, analgesic and anti-inflammatory activities as NSAIDs.