Revue des sciences chimiques

Synthesis and Comparison of Substituted Quinazolinone Analogs with Quinolones as Antitubercular and Antibacterial Agents

Abstract

R Subramaniam, G Rao

In recent years there has been a tremendous increase of drug resistant pathogens, especially M. tuberculosis, leading to the design and development of newer antimycobacterial compounds. The reaction of 3-amino-2-(2-chlorophenyl) quinazolin-4(3H)-one with various 2-chloro-N-(substituted phenyl)acetamide derivatives provided the target compounds. The structure of the compounds has been confirmed by IR, 1H NMR and Mass spectral data. Antitubercular and antibacterial activities were performed by microbroth dilution and cup plate method respectively. The compounds have shown significant antitubercular and moderate antibacterial activity when compared with the standard drugs.