Médecine moléculaire et génétique

Relevance to Psoriasis Pathophysiology: The Transcriptional Landscape of Repetitive Elements in Psoriatic Skin from Large Cohort Studies

Abstract

Logan Smith

Psoriasis, a chronic autoimmune skin disorder, has long been a subject of intensive research to decipher its complex pathophysiology. In recent years, advancements in genomics have opened new avenues for understanding the molecular intricacies underlying psoriasis. This article delves into the relevance of repetitive elements in psoriatic skin by examining the transcriptional landscape derived from large cohort studies. Through a comprehensive analysis of genomic data, this review aims to shed light on the involvement of repetitive elements in the pathophysiology of psoriasis, exploring their potential as biomarkers and therapeutic targets.