Médecine moléculaire et génétique

pH Sensitive Chitosan-based Supramolecular Gel for Oral Drug Delivery of Insulin

Abstract

Mohammad Reza Saboktakin, Abel Maharramov and Mohammadali Ramazanov

The main objective of this study is development of chitosan supramolecular gels to utilize for oral delivery of insulin. Chitosan (CS) blended dextran sulfate (DS) matrix as nanogels were characterized by scanning electron microscopy and FT-IR. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). Insulin entrapped in these gels and in vitro release profiles were established. In vitro release of insulin was also evaluated. The CS-DS gels have been developed based on the modulation of ratio show promise as a system for controlled delivery of the insulin to the stomach.