Médecine moléculaire et génétique

Genomic Approaches to Understanding the Pathogenesis of Neurodegenerative Diseases

Abstract

Cardos Garry*

Neurodegenerative Diseases (NDs) are a group of disorders that affect the central nervous system, causing progressive and irreversible deterioration of brain function. Despite extensive research efforts, the etiology and pathogenesis of NDs remain poorly understood. Genomic approaches, which involve the analysis of genes and their expression, DNA sequence variations and epigenetic modifications, have provided valuable insights into the mechanisms underlying NDs. In this paper, we review the latest advances in genomic research on NDs, including genome-wide association studies, transcriptomics, epigenetics and functional genomics. We also discuss the potential implications of these findings for the development of novel therapeutic approaches for NDs.