Journal de science de formulation et de biodisponibilité

Formulation and Development Challenges for a Carvedilol Liquid that is Pediatric-friendly

Abstract

Khadija Pérez-Lozano

Pediatric patients often present unique challenges when it comes to medication administration. Carvedilol, a widely used beta-blocker for the management of various cardiovascular conditions, is no exception. While it is typically available in tablet form for adult patients, formulating a safe, effective and palatable liquid formulation for pediatric use can be a complex and demanding task. In this article, we will explore the formulation and development challenges faced in creating a pediatric-friendly carvedilol liquid. Children can suffer from a wide range of cardiovascular conditions, such as hypertension, heart failure, or arrhythmias, for which carvedilol may be a suitable treatment option. However, administering tablets to pediatric patients can be problematic. Children often struggle to swallow pills and the dosing accuracy for tablets can be challenging. Furthermore, many pediatric patients require customized dosing, which is more easily achieved with liquid formulations.