Journal de bio-ingénierie et des sciences biomédicales

Design and Characterization of Mucoadhesive Microspheres for Gastro- Retentive Delivery of Famotidine Hydrochloride

Abstract

Shanthi Priya CH

This article illustrates the Design and Characterization of Mucoadhesive microspheres with Famotidine Hydrochloride as drug for Gastro-Retention of drug release. The microspheres were prepared by the Ion Gelation method and Thermal Cross Linking Method. In Ion Gelation method sodium alginate is used as a release controlling biopolymer and Calcium chloride is acts as hygroscopic cross linking agent. In Thermal Cross Linking Method egg albumin is used as binding agent and a Thermal energy is used as cross linking property. The characteristics like shape and structure of prepared microspheres by Optical microscopy and scanning electron microscopy, respectively. In vitro drug release studies were done and drug release was evaluated. Effect on the Mucoadhesion, drug Entrapment Efficiency of microspheres and Drug release were observed. The prepared microspheres exhibited prolonged drug release (17 hrs) the mean particle size increased as the concentration of sodium alginate increased, as the egg albumin concentration increases the Mucoadhesion increased and the drug release rate decreased at higher concentration of sodium alginate. Significant effect of the Encapsulation Efficiency of microspheres was observed. In vitro studies demonstrated the Gastro retentive delivery of drug from the microspheres.