Médecine moléculaire et génétique

Circulating MicroRNAs in Colorectal Cancer

Abstract

Huang Q, Ge B, Hu M, Zhou J and Bai X

Colorectal cancer (CRC) poses a serious threat to the health of global populations. Screening for the early detection of CRC is important to improve patient survival. Circulating microRNAs (miRNAs, miRs), as nucleic acid markers, play variety of important roles in early screening, diagnosis, TNM stage and prognosis of CRC. In this review, an overview covers recent researches on the roles of circulating miRNAs and their variety potential values correlated with CRC. Studies on the detectable marker values of circulating miRNAs for CRC will help making a global consensus of procedures and standardized protocols to make their clinical transformation more reliable.