Journal de pharmacognosie et de produits naturels

Cardiac Depressant Activity of Erythrina variegata Linn on Isolated Frog-Heart

Abstract

Karthikeyan R and Koushik OS

Objective: Erythrina variegata Linn of the family leguminaceae is a medium sized deciduous small tree with prickly stems and branches, leaves with triangular leaflets and large coral red flowers and grows all over Bangladesh. Different parts of E. variegata have used in traditional medicine as nervine sedative, febrifuge, anti-asthmatic and antiepileptics.It is having the d-tubacurarine like activity. The present study was under taken to evaluate the cardiac depressant activity of Erythrina variegata in experimental animal model.
Materials and method: Aqueous extract of E. variegata was tested for cardiac depressant action by using frog isolated heart model. Different concentration of atropine sulphate is used along with plant water extract.
Results: The water extract shows the significant cardiac depressant activity.
Conclusion: The present study shows that E. variegata has significant cardiac depressant activity.