Journal de l'épilepsie

An Epileptic Seizure Disorder Characterized by Abnormal Cortical Development

Abstract

Ehung Chin

Three cases of the contortion of the cortical development are described a mixed strain canine and a Border Collie doggy with a focal and verbose cortical dysplasia, independently, and an alley cat with lissencephaly. All cases presented with intractable epilepsy and were euthanized, due to the cluster of epileptic seizures. The gross examination at postmortem revealed the morphologic revision of the telencephalic region in two cases. Histopathologically, a disorganization of the cortical lamination with the presence of megalic neurons, was set up in the focal cortical dysplasia case. An altered association of the white and argentine matter, with a loss of the normal neuronal distribution and altered neurons, characterized the verbose cortical dysplasia case. In the lissencephalic cat, there was no recognizable association of the brain with areas of neuroglial towel forming nodes in the leptomeningeal space. We explosively support the thesis that, as in humans, as well as in the veterinary cases, deformations of the cortical development could be the cause of refractory epilepsy.