Journal des bioprocédés et des biotechniques

An Easy Bioprocess for Long-Chain Peptide Catalyst Screening and Optimisation Used in the Asymmetric Aldol Reaction

Abstract

Suing Wang

The field of organic synthesis has undergone a remarkable transformation in recent years, driven by the desire to develop more efficient and environmentally friendly methods for the construction of complex molecules. One of the key strategies in this quest is the use of asymmetric synthesis, which allows chemists to selectively produce a single enantiomer of a compound, avoiding the formation of unwanted byproducts and reducing waste. The asymmetric aldol reaction is a fundamental transformation in organic chemistry, and its development has been a central focus of research in the field. In recent years, biocatalysis has emerged as a powerful tool for achieving high levels of enantioselectivity in various chemical reactions. Enzymes, as nature's catalysts, are capable of catalyzing complex reactions with high specificity and efficiency. However, the application of enzymes in asymmetric synthesis has often been limited by the availability of suitable catalysts and the challenges associated with their screening and optimization. This article delves into an innovative approach, an easy bioprocess, for the screening and optimization of longchain peptide catalysts used in the asymmetric aldol reaction.