Journal des bioprocédés et des biotechniques

A Quick Way to Lower Industrial Animal Cell Culture\'s Production of Ammonium and Lactic Acid Nathaniel Crough

Abstract

Nathaniel Crough

The production of ammonium and lactic acid is a major challenge in industrial animal cell culture, affecting cell growth, productivity, and product quality. Ammonium and lactic acid are by-products of metabolism, specifically from the breakdown of amino acids and glucose, respectively. Their accumulation can lead to a decrease in culture pH, cell viability, and overall productivity. Therefore, strategies to lower the production of these metabolites are crucial for optimizing cell culture processes. This article explores quick and effective methods to reduce the production of ammonium and lactic acid in industrial animal cell culture.