Médecine pulmonaire et respiratoire

Uterus and Cervix Metastasis of Lung Cancer: A Case Report

Abstract

Chun-Yao Huang, YI-Hsin Lee, Lim Kun Eng and Yao-Kuang Wu

A 57-year-old, postmenopausal woman was diagnosed with lung adenocarcinoma, T4N3M1b, stage IV with brain and bone metastases, in 2008. Five years following of chemotherapy and target therapy (Epidermal Growth Factor Receptor Inhibitors), the patient complained of increasing problems with lower abdominal pain, urination incontinence and abnormal vaginal bleeding. The magnetic resonance imaging examination revealed only infiltrative soft tissue tumor in the uterus, whole layered and extrauterine extension with urinary bladder involvement. There were no other abnormalities noted in the pelvic area such as colon, rectum or urological tract. Histological and immunohistochemical examinations of endocervical and endometrial biopsies revealed metastatic adenocarcinoma, with the staining reactivity as primary lung neoplasm. This is the first report of coincident metastases endometrium and cervix from primary lung cancer.