Technologies et recherche en matière de transplantation

Standard Formulae in Predicting Liver Volumes: A South East Asian Series of Adult Living Donors

Abstract

Lui SA, Bonney GK, Kow WCA, Iyer SG, Chang SKY and Madhavan KK

Introduction

Historically Urata et al. first described a formula, based on donor biometrics, to predict total liver volumes. Many centres have shown that such formulae have different accuracy based on the population studied. To date, no such study has been carried out in a South East Asian population. Our primary aim was to study the accuracy of seven internationally recognized formula. Secondarily we aimed to derive a formula for caluculating the weight of a liver graft using CT derived volume.

Methods

A prospectively held database of adult living donor liver transplants between July 1996 and January 2015 was interrogated. Only entries with complete data were included. Donors’ biometrics were tabulated with corresponding CT based volumetry and actual graft volumes and weight, using seven well recognized formulae derived from international centres. The accuracy of these formulae was compared to the CT generated volume. Finally a correlation formula between CT volume and actual graft weight was described.

Results

In the study period, 100 adult donors underwent donor hepatectomies for the purposes of living donation. 79 of these had complete data allowing downstream analysis. None of the seven formulae were accurate at predicting volume and were similar in accuracy. However, the estimated liver volumes using formulas by FuGui and A. Poovathumkavadil showed the same and closest correlation with CT predicted volumes (r² = 0.55). Finally, we derived a formula to calculate weight of the graft based on predicted CT volumetry (Weight (g) = 0.86 X Vol (cm³) + 72.5) with good accuracy (r² = 0.9).

Conclusion

For the first time to date, we describe here the most reliable formula for predicting liver volume in a South East Asian population. Also, with good accuracy we propose a formula for calculating the weight of a liver graft based on CT volumetry.