Rapports de cas cliniques et médicaux

Rapid Growing Amyloid Goiter Mimicking a Malignant Thyroid Tumor in 24-Year-Old-Male, Secondary Amyloidosis and End Stage kidney Failure

Abstract

Soukaina Elaouni*1,3,4, Jahid Ahmed1,3, Zouidia Fouad1,3, Bernoussi Zakia1,3, Emalki Omar2,3 and Znati Kaoutar1,3

Background: Rapid growing amyloid goiter (AG) is an extremely rare cause of thyroid gland hypertrophy associated with secondary forms of amyloidosis. Characterized by the presence of deposits extracellular amyloid protein in thyroid tissue in sufficient quantities to produce enlargement of the gland, it can be seen in chronic inflammatory disorders, with the common characteristic of amyloidotic renal failure. Case presentation: We present a case of 24-year-old male in euthyroid with AG secondary to ankylosing spondylitis and chronic renal failure. This showed a rapid enlargement of both thyroid lobes, eventually causing a loco-regional compression simulating a malignant process. Following total thyroidectomy, Diagnostic confirmation of amyloid goiter was established by microscopic examination. Conclusion: In daily practice, practitioners should discuss differential diagnosis in patients with comorbidities suggestive of amyloidosis. The entity may be already suspected by radiology, but cytological and histological examination of amyloid deposits remain the keys attributes to establish the correct diagnosis.