Journal de médecine et de pratique en oncologie

Plasmablastic Lymphomas of the Oral Cavity: About a Case

Abstract

Wilfried MBA, Bertrand C, Evrard S, El-Majjaoui S, El-Kacemi H, Kebdani T and Benjaafar N

Plasmablastic lymphoma is a variant of diffuse large B-cell lymphoma, observed mainly in the oral cavity in the immune compromised. Pathologists poorly recognize plasmoblastic lymphoma, in part because of its relatively rare appearance and unusual immunophenotype.

We admitted a 63-year-old patient with a history of ischemic stroke 6 years ago to supplement the management of recurrent non-Hodgkin’s lymphoma a (NHL). A biopsy for pathological confirmation is requested and results as follows: Immunohistochemical profile in favor of plasmoblastic lymphoma (Tumor cells are of a lymphoid nature weakly expressing the leukocyte common antigen LAC-B117PD7/26-DAKO, antibodies anti-CD138 expressed diffuse, anti-CD20, CD3, CD5, CD10, CD30 negative, anti-cytokeratin antibodies AE1 negative, anti-HMB45 negative The proliferation index Ki67: 60%. Magnetic resonance imaging found: a residual polyolobed tumoral mass of 41 × 17 mm attached to the level of the tongue’s brake, then infiltrating the floor to the level of digastric muscles pouring right after administration of contrast medium. He has benefited from 6 cures of chemotherapy with the DAEPOCH protocol, first cure on 13/09/2017 and sixth on 27/12/2017. The reassessment report showed a good clinical response on the end-of-treatment CT scan on 15/01/2018. The patient presents himself 6 months later with another local recurrence. It benefits from radiotherapy on the oral floor at the dose of 40 gray. The plasmoblastic lymphomas represent a distinct new subtype among diffuse large B cell lymphomas. The individualization of this new class of lymphoma provides a solid foundation for other molecular analyzes to define its pathogen.