Li-Hua Gao, Gui-Qiang Miao, Xue-Hui Zang, Hui Sun and Li-Hui Wang
Osteoarthritis is a common disease that affects the elderly peoples, with a detrimental effect on quality of life as a result of pain, and total joint replacement is usually the last option for end-stage osteoarthritis. However, for those whom have complex diseases, total joint replacement was limited. Thus, looking for an alternative way to relieve pain is necessary. Recently, bone marrow edema is has been demonstrated to associate with knee pain and osteoarthritis. Thus, targeting bone marrow edema may provide a promising approach for relieving knee pain and delayed osteoarthritis development and progression. The present study highlights the importance of bone marrow edema to recurrent knee pain, and demonstrates an alternative way for treating patients who have osteoarthritic knee pain caused by bone marrow edema, and are not suitable for total knee replacement as a result of contraindications such as multiple internal diseases and high risk of operation.
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