Journal de neurologie et médecine pédiatriques

Neuropathological Factors Contributing to Clinical Variability in Synucleinopathies

Abstract

Mortina Alam

Synucleinopathies, a group of neurodegenerative disorders characterized by the accumulation of alpha-synuclein aggregates, include Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB), and Multiple System Atrophy (MSA). Despite the shared pathological hallmark of alpha-synuclein deposition, these disorders exhibit significant clinical variability. This research article explores the neuropathological factors contributing to this variability, including differences in alpha-synuclein aggregation patterns, regional brain involvement, and interactions with other neurodegenerative processes. By integrating findings from recent studies, we aim to elucidate how these factors influence clinical presentation and progression across different synucleinopathies.