Médecine Nucléaire et Radiothérapie

Comparison of [68Ga]Ga-PSMA-HBED-CC PET versus Whole-Body Bone Scintigraphy for the Detection of Bone Metastases in Patients with Prostate Cancer

Abstract

Vera Schreiter, Maximilian Gericke, Uwe Heimann, Ingo Steffen, Lars Stelter, Martin H. Maurer, Bernd Hamm, Winfried Brenner, Dorothea Theilig, Johannes Kahn and Nils Friedemann Schreiter

Aim: To compare [68Ga]Ga-PSMA-HBED-CC PET and (99m)Tc-DPD bone scintigraphy for the detection of bone metastases from prostate cancer. Methods: [68Ga]Ga-PSMA-HBED-CC PET/CT and (99m)Tc-DPD bone scintigraphy in 19 men with histopathological proven prostate cancer were compared to each other for the sensitivity/specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) for the detection of bone metastases. Results: According to the standard of reference lesion-based analysis of [68Ga]Ga-PSMA-HBED-CC PET and (99m)Tc-DPD bone scintigraphy reached a sensitivity of 45.6%/34%, specificity of 86.4%/81.4%, accuracy of 60.5%/ 51.2%, positive predictive value of 85.5%/76.1%, and negative predictive value of 47.7%/41.4%, respectively. Conclusion: [68Ga]Ga-PSMA-HBED-CC PET could detect significantly more bone metastases in prostate cancer than (99m)Tc-DPD bone scintigraphy.