Médecine pulmonaire et respiratoire

Clinico- Immunological Parallels in Chronic Obstructive Bronchitis in Adolescents

Abstract

Muhayyo Kholjigitova

The aim of this work was to study the concentration of IL-8 in conjunction with clinical and functional parameters of the COB in adolescents. Surveyed 52 teenagers and young men suffering from COB aged 11 to 21 years old. The control group consisted of 22 healthy individuals. Options for clinical COB 3 subgroups were identified. To examine the extent of production of IL-8, depending on the severity of the disease showed that IL- 8 levels in the serum increased significantly PC. It is noted that higher concentrations of IL- 8 cytokine was observed in patients with severe chronic obstructive bronchitis. ERF also made observations in these patients, depending on the stage and severity of disease. When functional examination in adolescents with COB were indicators showed a reduction in FVC, FEV1, PEF, MEF25, MEF50, MEF75, MEF25-75 which corresponded to a mixed disorders of pulmonary ventilation function with a predominance of obstructive variant. Thus, in patients with COB stradayushih adolescent relationship marked functional performance parameters of pulmonary cytokine status, in particular IL- 8.