Journal de cytologie et d'histologie

Biological Similarities Between Mesenchymal Stem Cells (Mscs) and Fibroblasts

Abstract

Ali Ghodsizad, Tobias Voelkel, Jeannette M Moebius, Igor Gregoric, Viktor Bordel, Edith Straach, Sebastian Knöbel, Darius Widera, Oliver Seitz, Arjang Ruhparwar, Arjang Ruhparwar, Matthias Karck, Barbara Kaltschmidt, Christian Kaltschmidt and Christoph Piechaczek

Fibroblasts have been shown to possess the capacity to differentiate into follicular dendritic cells in lymph nodes and into myofibroblasts in wounded tissues. Here, we demonstrate that foreskin-derived fibroblasts also have the potential to differentiate into adipocytes and osteoblasts under cell culture, developed for the differentiation of bone marrow derived mesenchymal stem cells (BM-MSC).