Journal de biométrie et biostatistique

Bayesian Estimation of the Three Key Parameters in CT for the National Lung Screening Trial Data

Abstract

Ruiqi Liu, Beth Levitt, Tom Riley and Dongfeng Wu

In this study cancer screening likelihood method was used to analyze the CT scan group in the National Lung Screening Trial (NLST) data. Three key parameters: screening sensitivity, transition probability density from disease free to preclinical state, and sojourn time in the preclinical state, were estimated using Bayesian approach and Markov Chain Monte Carlo simulations. The sensitivity for lung cancer screening using CT scan is high; it does not depend on a patient’s age, and is slightly higher in females than in males. The transition probability from the disease-free to the preclinical state has a peak around age 70 for both genders, which agrees with the fact that the highest lung cancer incidence rate appears between age 65 and 74. The posterior mean sojourn time is around 1.5 years for all groups, and that explains why screening only have a short time interval to catch lung cancer. Accurate estimation of the three key parameters is critical for other estimations such as lead time and over-diagnosis, because these quantities are functions of the three key parameters.