Médecine alternative et intégrative

Abri Cantongnesis Modulates Detoxifying Enzymes to Ameliorate Hepatotoxicity in Rats

Abstract

Jing Zheng Song and John WS Ho

Abri cantongnesis in combination with herbs are used for treatment of diseases. However, the detail of its pharmacological activities is lacking. In this study, the chemoprotective effects of the active fraction of Abri cantongnesis on toxicant-induced liver toxicity in rats were studied. The Abri cantongnesis extract was orally administered to SD rats for three days before treatment of rats with trichloroethylene once for two days. Rat urines and hepatic enzymes were collected for analysis. The results showed that CYP 1A and CYP 2E1 and glutathione transferase increased over 45% while the activity of diaphorase increased by 30%. These enzyme activities were increased with the extract concentration. However, only UGT showed a decrease in activity upon treatment with Abri cantongnesis. The treatment of rats with Abri cantongnesis caused an increase in catalytic activities of CYP 1A and CYP 2E1, GST and diaphorase in the rat. The results show that Abri cantongnesis enhanced elimination of trichloroethylene and its metabolites; thus the treatment of Abri cantongnesis can reduce liver toxicity in rats. The findings suggest that Abri cantongnesis has chemopreventive effects on toxicants-induced hepatotoxicity in rats. The Abri cantongnesis can be used as a chemo-protective agent for the liver.