Chimie médicale

This article includes the synthesis of thiazolidinone based heterocyclic derivatives has been presented. 2-2-(5-(4-methoxyphenyl)-3phenyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methyl-4-oxo-3-substituted phenyl thiazolidin- 5-yl) acetic acid were synthesised by condensation of (E)-3-(4-(methoxy) phenyl)-1-phenylprop-2-en-1-one with acetic acid and hydrazine followed by cyclization of Schiff’s bases with 2-mercaptosucicinic acid to give corresponding derivatives of 2-(2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-2-methyl-4-oxo-3-phenylthiazolidin- 5-yl)acetic acid. Thiazolidinones play an important role in medicinal chemistry, because many of its derivatives have demonstrated significant biological activity. These compounds have shown biological activity as antibacterial and anti-inflammatory activities this structure of synthesized compounds was confirmed by spectral studies (IR and 1H-NMR) and elemental analysis. The antibacterial activity of the compounds has also been screened against Staphylococcus aureus and Escherichia coli.