Journal d'histologie moléculaire et de physiologie médicale

The study investigated the effects of neonatal maternal separation on brain development, emphasizing the emergence of sexual dimorphism in the neural structure and function. Using a rodent model, we examined the impact of early-life separation from dams on various aspects of brain development, including morphology, connectivity, and neurochemical profiles. Our findings suggest that neonatal maternal separation leads to distinct patterns of brain development in male and female subjects, highlighting the importance of early-life experiences in shaping sexual dimorphism in the brain.

The human body comprises countless cells, each dedicated to executing precise functions that collectively uphold the intricate equilibrium of life. Grasping the intricacies of cellular physiology is indispensable for deciphering the intricate machinery governing our biological systems. This article embarks on a journey into the fascinating realm of cellular physiology, delving into the essential building blocks, energy generation, cellular signaling, and regulatory mechanisms that empower cells to operate in perfect harmony.

Drug candidates have the potential to trigger hepatic steatosis, a condition characterized by the accumulation of lipids in liver cells without observable morphological alterations. Clinical investigations have identified two distinct fat deposition patterns: diffuse and non-diffuse. The more prevalent diffuse pattern contrasts with the non-diffuse category, which encompasses various subtypes, including geographic, focal, sub-capsular, multifocal, and perivascular patterns. Given the narrow safety margins associated with drug-induced hepatic steatosis, it is imperative to devise means for monitoring its incidence and severity in both preclinical and clinical research settings. Nevertheless, the conventional gold standard for diagnosing hepatic steatosis, liver biopsy, presents numerous drawbacks such as invasiveness, risk of bleeding and complications, as well as sampling inaccuracies due to the uneven distribution of fat within the liver. Consequently, liver biopsy falls short in terms of suitability for monitoring drug-induced hepatic steatosis, leaving a void in established monitoring methods for this condition.

Computed Tomography (CT) imaging plays a pivotal role in diagnosing, characterizing, predicting outcomes, and tracking disease progression in individuals affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Yet, for a consistent and dependable assessment of pulmonary irregularities, precise segmentation and quantification of both the complete lung and lung lesions (anomalies) in chest CT scans of COVID-19 patients are indispensable. Regrettably, the manual segmentation and quantification of extensive datasets can prove time-intensive and yield low levels of agreement both between different observers and within the same observer, even among experienced radiologists.

Methicillin-resistant S. aureus poses a significant public health risk due to its resistance to multiple antibiotics. Accurate MRSA detection is paramount for effective treatment and containment of bacterial spread. A promising approach involves employing molecular biosensors based on Surface-Enhanced Raman Scattering (SERS). SERS is a robust analytical technique extensively applied in the detection of biological molecules.

Histology, often referred to as microscopic anatomy, investigates the cellular and molecular structure and function of tissues and organs. This discipline plays a pivotal role in unraveling the intricate workings of living organisms and boasts numerous practical applications across various domains, including medicine, biology, and beyond. In my view, the significance of microscopic anatomy cannot be emphasized enough.

Histological analysis is a crucial field in medicine, focusing on the examination of tissues and organ structures at the microscopic level. Its significance lies in aiding the diagnosis and treatment of various medical conditions. In this context, we introduce a patient case in which a liver biopsy unveiled an exceptionally uncommon histological observation.

Endocrinology, a specialized field of medicine, delves into the intricate study of hormones and their profound impact on the human body. These hormones, acting as potent chemical messengers, originate from various glands within the body. Their pivotal role involves the regulation of diverse physiological processes, including but not limited to growth, metabolism, and reproductive functions. Within the realm of endocrinology, one explores the multifaceted aspects of hormones, encompassing their synthesis, secretion, and the intricate orchestration of their effects on the body's organs and tissues.

Cellular biology, alternatively referred to as cytology, delves into the examination of cells, scrutinizing their composition, operations, and interplay. This discipline holds a pivotal role in the realm of scientific inquiry, as cells serve as the fundamental building blocks of life, orchestrating the vital processes essential for an organism's sustenance and prosperity. Within the confines of this article, we shall embark on a journey through the annals of cytology's history, acquaint ourselves with the instruments wielded in its pursuit, and delve into the consequential breakthroughs that have enriched this domain.

Bioenergetics delves into the intricate processes through which living organisms convert energy from one state to another. This field stands as a cornerstone of biology, given that energy plays a pivotal role in vital biological functions like growth, mobility, and reproduction. Bioenergetics primarily centers on elucidating the intricate mechanisms governing the generation, storage, and utilization of energy within cells and organisms.