Journal sur le SIDA et la recherche clinique

Viral Suppression in the Setting of Multidrug Resistance to Nelfinavir, Tenofovir and Abacavir: A Case Report

Abstract

Amy M Cheng, Rustin D Crutchley, Meghann L Davis, Carl Mayberry and Joseph C Gathe Jr

One major barrier to achieving the primary goals of antiretroviral therapy is the development of drug resistance mutations to antiretroviral agents which render them less effective. For patients who are treatment experienced with many drug resistance mutations, selection of an effective antiretroviral regimen becomes challenging. We report a case of a 55 year old male on tenofovir, abacavir and nelfinavir with multiple resistance mutations to each of these agents, yet able to maintain viral suppression and high CD4 T cell counts. This patient was subsequently switched to protease inhibitor monotherapy for the management of HIV in the setting of multidrug resistance.