Toxicologie environnementale et analytique

The Role of Oxidative Stress in Carcinogenesis Induced By Metals in Breast Cancer Egyptian Females Sample at Dakahlia Governorate

Abstract

Ahmed R. Ragab *,Omar Farouk ,Mostafa M. Afify ,Afaf M. Attia ,Ayman El Samanoudy ,Yasmeen M. Taalab

Trace metals and metals induced Oxidative stress have been implicated in breast carcinogenesis. Our study aimed to evaluate alteration of trace metals in breast tissue, oxidative stress and antioxidant status in breast cancer patients. This study included 120 female patients: 100 with breast cancer and 20 with benign breast diseases. Trace metals in breast tissue, lipid peroxidation and oxidative status were assessed. The present Results showed a significant increase in lead, cadmium, chromium, nickel and iron concentrations in malignant breast tissues compared to control group (P < 0.001). Also, a significant decline in Glutathione-S-transferase (GST), Glutathione Reductase (GR) and Total Antioxidant Capacity (TAC) levels; however a significant rise in Malondialdehyde (MDA) and Ferritin levels was detected in patients with breast cancer compared to controls. In conclusion, the alteration of the elemental content in cancerous breast tissues and the disruption of oxidant/antioxidant balance highlight the role of trace metals in cancer development.