Science et thérapie du cancer

The Cutaneous Involvement of Multiple Myeloma as an Indicator of Unfavorable Evolution: Series of Three Cases

Abstract

Flavia Zattar Piazera*, Rafael de Sa Vasconcelos, Marcelo Jorge Carneiro, Alexandre Nonino, Jorge Vaz Pinto Neto, Luiz Henrique Ramos Athaídes and Selma Kuckelhaus

Cutaneous myeloma, a rare clinical presentation of multiple myeloma, is usually associated with high burden of malignant cells and poor prognosis. Three cases who were diagnosed with multiple myeloma and exhibited cutaneous involvement with a wide range of clinical manifestations. We emphasize the morphologic and immunohistochemical patterns of this rare presentation. The use of new therapies associated double or triple regimens in the treatment of myeloma showed significant improvements in progression-free survival, but relapse with cutanea infiltration suggests a pattern of aggressiveness that is still unclear and generally refractory to conventional therapies. The pathophysiology and the findings and markers that might be associated with prognosis based on the review of recent literature.