Chimie médicale

Synthesis of Putrescine Bisamides as Antimicrobial and Anti-Inflammatory Agents

Abstract

Srinuvasarao Rayavarapu, Sunanda Kumari Kadiri, Mahaboob Basha Gajula, Mangarao Nakka, Ramu Tadikonda, Nagendra Sastry Yarla and Siddaiah Vidavalur

A new naturally occurring N1, N6-dihydrocinnamyl putrescine bisamide, JBIR-94, along with nine structural analogs and a series of substituted phenyl and alkyl putrescine bisamides have been synthesized from putrescine and appropriately substituted carboxylic acids, through carboxylic acid chlorides. Antimicrobial, 5-Lipooxygenase enzyme inhibitory and antioxidant studies were performed for all synthesized compounds. Dihydrocinnamyl series of putrescine bisamides (4a-4i) showed good bioactivities compared to substituted phenyl (6a-6g) and diakyl (6h-6j) series of compounds. Among all compounds, 4h (methylenedioxy analog) and 4a (JBIR-94) showed good antimicrobial, antiinflammatoryand antioxidant activities.