Chimie médicale

Synthesis, Characterization, Molecular Docking, Cytotoxic and Antioxidant Activities of Di(indolyl)thiazolylpyrazoles

Abstract

Nagarjuna U, Madhusekhar M, Trinath D, Kumaraswamy Naidu C, Suneetha Y, Padmavathi V and Padmaja A

Some new di(indolyl)thiazolylpyrazoles were prepared from the synthetic intermediate E-1,3-di(1H-indol-3-yl) prop-2-en-1-one under ultrasonication and studied their cytotoxic and antioxidant activities. All the compounds were screened for in vitro cytotoxic activity on three cancer cell lines. The compound 7e exhibited appreciable anticancer activity on NCI-H1299, HCT-166 p53 and PC-3 cancer cell lines. The binding conformation of the target molecules was predicted by docking methodology to explain the biological activities. In fact, the docking studies indicated that could be used as possible leads for therapies against cancers. Amongst all the tested compounds dimethoxy substituted di(indolyl)thiazolylpyrazole (7i) displayed significant radical scavenging activity.