..
Soumettre le manuscrit arrow_forward arrow_forward ..

Synthesis and Anti-Cancer Evaluation of Spiro-indolinone Derivatives

Abstract

Liang Hong, Jie Tong, Guangliang Yu and Chunqi Hu

A series of spiro-indolin-2-one derivatives were designed and synthesized as p53-MDM2 binding inhibitors. Though p53-MDM2 binding inhibitory and activities against p53 wild-type cell lines of most compounds were not that promising, some obtained structures showed moderate to strong inhibitory activities (IC50<0.08 μM) against p53 mutant cell lines (SW620), suggesting that these compounds may have different modes of action to p53 pathway, further studies on treatment of p53 mutant tumors are under investigation.cc

Avertissement: Ce résumé a été traduit à l'aide d'outils d'intelligence artificielle et n'a pas encore été examiné ni vérifié

Partagez cet article

Indexé dans

arrow_upward arrow_upward