Troubles neurologiques

Spectral Analyses of Heart Rate Variability by Acceleration Plethysmography for Diagnostic Support of Migraine: Clinical Research

Abstract

Shigeki Edahiro, Takahiro Maruta, Masako Negami, Yumi Adachi and Hiroaki Yoshikawa

It is suspected that the pathophysiology of migraine has a relation to the autonomic dysfunction. We studied to assess the autonomic function in migraine using the spectral analysis of heart rate variability (HRV) by accelerated plethysmography (APG). Five-hundred-twenty-four patients received the health check-ups in an affiliated hospital since September, 2011 to April, 2013. Eighty-three patients with headache and 38 controls were enrolled in this study. The patients were subdivided into 19 with migraine (19 female), 26 with tension-type headache (TTH) (7 male, 19 female) and 31 of other headaches using a questionnaire based on the International Classification of Headache Disorders 2nd Edition. Patients with migraine or tension-type headache underwent examinations using APG with an orthostatic load. Twenty-four controls without headache received same examinations. As a result, the standing/sitting ratio of spectral power of high-frequency (HF) in the migraine group was higher than those of TTH (p=0.0277) and normal controls (p=0.0104). The cut-off value of 1.058 could separate migraine from TTH with sensitivity of 0.632 and specificity of 0.846. The results suggested that the parasympathetic activity accentuated by orthostatic load in patients with migraine, on the contrarily the parasympathetic activities diminished by orthostatic load in patients with TTH or normal controls. This study showed that spectral analysis of HRV by APG is a supportive tool to distinguish migraine from TTH.